#1
Been playing through the awesome VTMB recently and can't help but absolutely love the Malkavian clan. For instance, where else would you actually have a conversation with a "STOP!" sign. I don't think any game has had me in stitches as much as this at some of the absolutely brilliant one-liners that your character comes up with.  
Other than the aforementioned incident, here are some of my top quotes (as best as I can remember them) from my recent playthough. I may add to this as I continue playing.  
When speaking to a trader about buying guns: 
"Guns never solved any problem. I'll take twelve."  When speaking to VV regarding a vampire hunter. She says she has had one right under her nose: 
"That's one tiny hunter!"  When speaking to Becket about why I think Vampires exist: 
"The reason we exist is because the Jellyfish will it so. WHY ELSE?"  When convincing Samantha that you are not who she thinks you are - you say you are a turtle. She asks what it is like being a Turtle: 
"It's like being a walking house that eats lettuce."  When recognising a certain NPC: 
"You look familiar. Were you ever on a milk carton?"  When my pet ghoul, Heather starts to go a little crazy and says she had tapped her foot over 3,000 times while I was gone: 
"Now we know how many foot taps it takes to make me appear. Wonderful."